MS Imaging of Paraffin-Embedded Tissue Sections
MS imaging of paraffin-embedded tissue sections of human endometrial cancer and ovarian cancer
Similarly, paraffin-embedded tissue sections of human ovarian cancer were de-paraffinized, trypsin and DHB matrix added by CHIP-1000, and MS/MS analysis performed using an AXIMA-QIT to directly identify the proteins in the sections. This allowed the detection and identification of multiple proteins, particularly the structural proteins comprising the cytoskeleton.
|Reference:||Yutaka Aoki et al (2007), "Potentiality of Drug Discovery with MALDI-MS Imaging System," Shimadzu Review 63 (3/4)|
MALDI-TOF MS Imaging System
- The CHIP-1000 Chemical Printer can dispense trace, pico-liter, levels of a diverse range of reagents including matrix solutions and enzyme solutions. It delivers exceptional reproducibility unachievable using spray methods.
- CHIP-1000 allows highly reproducible MALDI-TOF MS imaging.
- Allows the MALDI-TOF MS imaging, identification, and structural analysis of diverse molecules, ranging from lipids and low-molecular compounds to peptides and proteins.
- The acquired MS data can be read and analyzed using existing MS imaging software, such as BioMap (http://www.maldi-msi.org/).
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