SPECIALLY COLLECTED PAPERS
Shimadzu Review 74[3・4] (2017.12)
Abstract
We have developed the MSW2 microsampling device, a handy tool to seamlessly quantify exact volumes of plasma for toxicokinetic or pharmacokinetic evaluation in non-clinical studies. MSW2 is composed of two components, the Microsampling Wing for sampling blood and the Microsampling Windmill for supporting the Microsampling Wing in the centrifugation and storage processes. By combining these two components, a plasma volume of 8.1 µL max. (usually 5.6 µL) can be easily quantified from 23 µL of whole blood without technical difficulties. MSW2 is not only able to improve work efficiency but, by using the advantages of sampling micro-L volumes (microsampling), it is also able to contribute to animal welfare, reducing unnecessary experiments and stress on animals due to sampling.
In this article, we evaluate the accuracy and precision while comparing MSW2 with a micropipette method.
Keywords: Non-clinical, Microsampling, Animal welfare, 3Rs, Toxicokinetics, Pharmacokinetics
1Optical Components Business Unit, Device Department, Shimadzu Corporation, Kyoto, Japan
2Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan
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