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Shimadzu Review 77[1・2] (2020.7)
Abstract
The separation and purification of target compounds and impurities from samples is an essential step in drug research and development, and preparative chromatography that recovers components after separation is the unit operation most commonly utilized for this step. Supercritical fluid chromatography (SFC) can complete preparative separation tasks quicker than liquid chromatography (LC), which uses organic solvent as the mobile phase, and industry has awaited the development of preparative SFC systems that meet the needs of pharmaceutical companies.
In the United States, Enabling Technologies Consortium (ETC) is a consortium of 12 pharmaceutical companies that conducts collaborative research on new technologies required for drug research and development. ETC is in the advanta-geous position of being able to define technical requirements collectively and to spread the economic burden of evalua-tions between consortium companies through the conduct of joint evaluations.
This article introduces a semi-preparative SFC project undertaken together with ETC and describes examples where efficiency was improved by using the instrument developed by this project as a preparative unit operation.
1Shimadzu Scientific Instruments, Inc. , Maryland, U.S.A.
2LC Business Unit, Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan
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