TOC Measurement of Pharmaceutical Water

User Benefits

・Quick and easy control of organic impurities in pharmaceutical water is possible by using a Shimadzu TOC analyzer. ・Highly accurate measurement of pharmaceutical water with TOC concentrations of several 10 μgC/L is possible with both the combustion catalytic oxidation type TOC-L and the wet chemical oxidation type TOC-V.

Introduction

Pharmaceutical water used in drug manufacturing processes must have a high level of safety and minimal impurities. Total organic carbon (TOC) is used in control of organic impurities in pharmaceutical water, and control standards corresponding to the application are provided in the pharmacopoeias used in various countries. For example, the Japanese Pharmacopoeia (JP) sets a limit of “not more than 0.500mg/L” for TOC in purified water and water for injection (bulk). Quick and easy control of organic impurities is possible with Shimadzu TOC analyzers, even in cases where measurement with this high sensitivity/high accuracy is required. Application News No.081 introduced online measurement of ultrapure water with the TOC-1000e. This article introduces an example of measurement of pharmaceutical water with the combustion catalytic oxidation type TOC-L and the wet chemical oxidation type TOC-V, which enable batch measurement in the laboratory.

30 de abril de 2021 GMT