Preparative Purification of Ibuprofen and Related Substances by Nexera UFPLC

User Benefits

- Fully automated purification process (Fractionation, purification, concentration, recovery, etc.) significantly reduces the operator workload and improves the overall analytical efficiency. - Target compounds can be recovered after removing the salt contained in the mobile phase solvent. - The time required for the drying process of the fraction can be reduced because the fraction with a high content of organic solvent can be recovered.

Introduction

Preparation and purification by liquid chromatography is a widely-used technique in the pharmaceutical, food, and chemical industries for drug synthesis, finding effective compounds in natural products, and for structural analysis of unknown trace compounds. Nexera UFPLC enables substantial labor savings in preparative purification by automating not only the fractionation of the target compound but also related processes such as concentration, purification, and recovery. This article describes an example of preparative purification of a mixed sample of the pharmaceutical ibuprofen and its analogues using Nexera UFPLC.

27 de julio de 2023 GMT