An Oligonucleotide Impurity Analysis Workflow Using LabSolutions Insight™ Biologics Software

User Benefits

・LabSolutions Insight Biologics software offers a simple workflow for the characterization of oligonucleotides and oligonucleotide impurities. ・Allows comprehensive characterization of oligonucleotide impurities. ・Fragment coverage is shown in a simple graphical format that highlights missing and modified nucleotides.

Introduction

Oligonucleotide therapeutics have undergone rapid development in recent years and are attracting interest as a new modality in drug discovery. Such development has created a demand for the comprehensive detection and identification of impurities in oligonucleotide therapeutics to ensure their safety and efficacy. This Application News describes an impurity analysis workflow for oligonucleotides based on the LCMS-9050 quadrupole time-of-flight mass spectrometer system and LabSolutions Insight Biologics software.

July 17, 2023 GMT