Differential Analysis of Aging by Sex Using Correlation Analysis of Primary Metabolites

User Benefits

- Smart Metabolites Database™ Ver. 2 realizes an effortless implementation of a primary metabolites analysis. - Multi-omics Analysis Package reveals characteristic compounds of each sample group by visualizing the metabolite amounts in a metabolic pathway and performing age-specific and correlation analyses on the pathway map.

Introduction

Since the elderly are at high risk of developing diseases and tend to develop them for a long time, Japan has a medical system for the elderly that differs from other age groups. Age-related changes in physical function are a factor contributing to the worsening of morbidity, and it has been reported in the literature that postprandial blood glucose tends to spike due to abnormal glucose metabolism, and fatty acid capacity stored in the liver decreases due to abnormal lipid metabolism. There is also a difference in the age-related health status change among the same elderly people according to the gender. Men tend to suffer from lifestyle-related diseases such as heart disease and stroke and need assistance, while women tend to have decreased mobility and independence due to bone and muscle weakness . These differences are also thought to be influenced by changes in the amount of primary metabolites. Therefore, it is of utmost importance to clarify the differences in the amount of metabolites between the genders in the elderly. In this application, primary metabolites in the serum of healthy subjects aged 70 to 85 were measured by gas chromatograph mass spectrometer (GC-MS). In order to find differences between the genders, Multi-omics Analysis Package statistical software was used. Multi-omics Analysis package is a software that provides data visualizations such as multivariate analysis (such as principal component analysis and rank cluster analysis), volcano plots, and metabolic maps. Here is an example of an analysis that visualizes the primary metabolite measurement data in a metabolic pathway diagram and analyzes the differences by sex by age and correlation analysis.

12 de septiembre de 2023 GMT