Structural Confirmation of Polyoxazoline Conjugated Albumin (New Artificial Blood) Using a Benchtop MALDI-TOF MS System

Introduction

The demand for animal medical care, especially pet healthcare, continues to increase every year, but the infrastructure for blood transfusion therapy remains inadequate. Recently, we (Komatsu Lab team, Chuo University) have developed a new artificial blood product (artificial plasma) for pets “polyoxazoline conjugated albumin.” This formulation is created by chemically modification of readily available porcine-derived albumin with polyoxazoline and can be safely administered to dogs and cats. In this paper, we describe an example of structural confirmation of POx-PSA using a matrix-assisted laser desorption/ionization-time of flight mass spectrometer (MALDI-TOFMS).

October 31, 2023 GMT