Simultaneous Analysis of Hydrophilic Metabolites in Feces Using a Single Quadrupole Mass Spectrometer

User Benefits

- The single quadrupole LC-MS system allows for simple, simultaneous analysis of hydrophilic metabolites in feces. - The Multi-omics Analysis Package offers a simple tool for data analysis including multivariate analysis, and it allows users to find characteristic compounds with ease.

Introduction

Human intestines are home to around 1,000 different species of approximately 100 trillion intestinal bacteria. It is becoming increasingly clear that these intestinal bacteria help maintain and improve the health of their host, and research into intestinal microbiota has been attracting increasing interest. In the medical domain, the relationship between intestinal microbiota and diseases, such as colorectal cancer, and the effects of intestinal microbiota on drug efficacy and the immune system are being investigated. In the food domain, the beneficial effects of lactic acid bacteria found in functionally enhanced foods are also being investigated. Since short-chain fatty acids and other metabolites produced by intestinal bacteria affect the host, analysis of these metabolites is important for the research of intestinal bacteria. This Application News describes simultaneous analysis of hydrophilic metabolites in feces using a single quadrupole LC-MS. Application News No. 01-00601-EN describes a method for the analysis of short-chain fatty acids and organic acids, and combining that method with the method described here offers an approach for a comprehensive analysis of metabolites in feces.

December 5, 2023 GMT