Identification Test of the Ibuprofen Active Ingredient Compliant with European Pharmacopoeia and UnitedStates Pharmacopeiaand Analysis of Final Product(Commercial Pharmaceutical) by ATR Method

User Benefits

- A variety of infrared spectroscopy techniques can be used to easily perform identification tests for not only ibuprofen drug substances but also final products (commercial drugs). - Identification tests compliant with European Pharmacopoeia and United States Pharmacopeia requirements can be easily performed using an IRSpirit-ZX spectrophotometer. - The IRSpirit-ZX offers high humidity resistance for worry-free operations even in high-temperature and high-humidity environments.

Introduction

Infrared spectrophotometers are commonly used in combination with ultraviolet-visible spectrophotometers to perform identification tests of pharmaceuticals. The infrared spectroscopy method measures the degree of light absorption at each wavenumber as infrared light passes through the sample. The infrared spectrum shows the wavenumbers where light is absorbed and the intensity of that absorption, which are determined by the chemical structure and concentration of the target substances. Consequently, it can be used to identify or quantitate substances. The pharmacopoeia of a country usually specifies the same measurement techniques for the same samples, but in a few rare cases, they specify different measurement techniques. This article describes differences in results obtained using the different identification test techniques specified for ibuprofen active ingredients in the European Pharmacopoeia (EP) and the United States Pharmacopeia-National Formulary (USP-NF). The article also describes using an ATR attachment to analyze not only the active ingredient but also the final drug product, which is the commercially marketed pharmaceutical.

22 de enero de 2024 GMT