Simultaneous Quantitation of 32 PFAS in Baby Food by LC-MS/MS

User Benefits

- A simple QuEChERS extraction procedure has been employed for quantifying the PFAS with normal dSPE cleanup. - This method complies with all acceptance criteria (as per AOAC SMPR 2023.003) without using ISTDs. - Method with shorter run time can contribute to achieving high throughputs in testing laboratories.

Introduction

PFAS (Per- and polyfluoroalkyl substances) are a class of highly persistent chemicals widely known as "forever chemicals" due to their strong resistance to environmental degradation. Found in products like firefighting foams, non-stick cookware, and water-resistant fabrics, PFAS are now recognized as major environmental and health concerns. These substances accumulate in soil, water, and living organisms, including humans, where they may cause serious health impacts over time. Given their potential for long-term contamination, the detection and quantification of PFAS are critical. Advanced analytical methods, particularly LC-MS/MS with Multiple Reaction Monitoring (MRM), offer the specificity and sensitivity needed to accurately measure PFAS concentrations. However, one of the primary challenges in PFAS analysis is minimizing background contamination from PFAS residues within the LC system and during sample collection and preparation. Effective strategies to reduce these sources of contamination are essential for reliable results in PFAS quantification. Compared the recovery and precision against the requirements of AOAC SMPR 2023.003. In addition, we determined the Limit of Quantitation (LOQ) as the lowest concentration meeting recovery accuracy and precision. All recovery, precision, and LOQ’s met the acceptance criteria. We optimized the chromatography and instrument operating parameters to achieve excellent peak shape, separation, and sensitivity.

19 de noviembre de 2024 GMT