Rapid, Highly Sensitive and Direct Quantification of Fluticasone Propionate at Sub-pg/mL in Plasma Using LCMS-8060

User Benefits

- Rapid, simple and sensitive method with LLOQ of 0.2 pg/mL - Single step sample extraction method increased sample productivity

Introduction

Fluticasone propionate, a medium-potency synthetic corticosteroid is administered as nasal spray or drops for the treatment of allergic and non-allergic rhinitis; or by oral inhalation for the treatment of asthma. Therapeutic dose of fluticasone propionate results in very low plasma concentrations and requires a sensitive bioanalytical method for accurate quantification of the drug in plasma. Shimadzu Application Development Centre (ADC), Navi Mumbai has developed and validated the most sensitive method with lowest limit of quantification (LLOQ) of 0.2 pg/mL. The method has used a single step sample extraction technique and direction injection approach to eliminate environmental contamination. These factors enhance productivity of the pharmacokinetic investigation involving high-throughput analysis.

18 de diciembre de 2024 GMT