Cap Structural Analysis - mRNA Therapeutics and Vaccines

This quadrupole time-of-flight (Q-TOF) mass spectrometer offers the highest class of mass accuracy reliability. Shimadzu’s unique high-precision temperature control system suppresses even tiny mass variations caused by external factors, ensuring accurate mass measurements without the operator worrying about mass calibration. Insight Biologics oligonucleic acid sequencing software can identify oligonucleic acid impurities and confirm sequences with predicted modification positions.

This single quadrupole mass spectrometer can be integrated into an LC system and operated with the same ease as an LC detector. Due to its wide mass range from m/z 2 to 2000 and the large number of detectable valence ions, it is possible to calculate the molecular weight of oligonucleic acids and other medium-sized molecules with high reliability using the deconvolution function. When analyzing using a UV detector in combination with the LCMS-2050, it is also possible to overlay mass information on the chromatograms.

Operations to identify oligonucleic acid impurities or to predict the position of modifications based on complex mass spectra are typically extremely time-consuming. Moreover, using multiple software programs for measuring masses and analyzing data makes operations complex and increases the operator’s workload. Insight Biologics solves such problems and provides a far better user experience.