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    Imaging Mass Microscope

    With mass spectrometry imaging (MSI), suitable pretreatment is important. High quality MSI analysis results are obtained from a combination of the spray method and the vapor deposition method.

    Work Flow

    Automatic Sprayer
    iMLayer AERO (Option)

    The iMLayer AERO incorporates a sample stage that moves at a controlled rate while maintaining the same distance from the spray nozzle, enabling stable matrix spraying. Over multiple strokes, the sample becomes laminated with fine matrix crystals, enabling high sensitivity and high spatial resolution.

    iMLayer AERO

    Imaging with High Reproducibility

    Humidity Control

    Humidity does not impact matrix deposition because the atmosphere within the spray chamber is replaced before pretreatment. Spraying can be performed under more stable conditions than with a hand spray.

    Humidity Control

    Clog-Free Reagent Delivery

    If the matrix clogs the nozzle tip, the spray becomes unstable, which can lead to lower reproducibility. The rinsing mechanism allows for clog-free stable spraying which enables high reproducibility in MALDI analyses.

    Clog-Free Reagent Delivery

    Matrix Vapor Deposition System
    iMLayer (Option)

    Applying the matrix by the vapor deposition method supports high resolution MALDI imaging.

    iMLayer

    Both Spatial Resolution and Sensitivity Thanks to the Two-Step Vapor Deposition Method

    Two-Step Vapor Deposition

    iA two-step vapor deposition method has been developed*, which  provides high spatial resolution (5 to 10 μm) and high sensitivity,  thanks to a combination of iMLayer (vapor deposition method) and  iMLayer AERO (spray method). This unique experiment can only be  implemented using Shimadzu sample preparation solutions.

    * Patent No.: JP6153139 and JP6183779

    Two-Step Vapor Deposition

    IMAGEREVEAL™ MS
    Mass spectrometry imaging data analysis software

    Automatically uncover important information from large amounts of data with IMAGEREVEAL MS.

    IMAGEREVEAL MS 

    Related information

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