Multimodal Imaging System - Features

The gadolinium contrast medium Gadofluorine P exhibits a high affinity for the collagen-rich extracellular matrix secreted in cases of myocardial infarction.
Gadofluorine P was administered to a myocardial infarction model mouse and the distribution of Gadofluorine P in mouse cardiac tissue was observed.
Elemental imaging of gadolinium in the contrast medium was performed by LA-ICP-MS (top) and iMScope was used for molecular imaging of molecules with the same structure as Gadofluorine P (bottom). Combining these two imaging techniques enabled visualization of gadolinium contrast medium distributed in the cardiac tissue of the myocardial infarction model mouse.

5,10,15,20-Tetrakis(3-hydroxyphenyl)porphyrin (mTHPP) is a photosensitizer used in photodynamic therapy, a type of cancer treatment. A tumor spheroid derived from HT-29 human colonic adenocarcinoma cells was separately immersed in mTHPP and mTHPP-Pd (mTHPP labeled with metallic palladium) and the distribution of mTHPP and mTHPP-Pd in the tumor spheroid was observed. Elemental imaging of palladium by LA-ICP-MS (top) and molecular imaging of mTHPP with iMScope (bottom) show the same distribution of mTHPP and mTHPP-Pd. Elemental imaging by LA-ICP-MS provides quantitative information in addition to the elemental distribution.