This pretreatment kit for human biological samples is intended for the field of forensic medicine.
LCMS-8050 - Options
High Performance Liquid Chromatograph Triple Quadrupole Mass Spectrometer
Ionization Unit
Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.
LCMS-8050 Upgrade to LCMS-8060
Enhanced performance for the LCMS-8050
The world’s greatest sensitivity and ultra-fast technologies found in the LCMS-8060 are now available for the 8050.
The LCMS-8050 Upgrade Kit includes three key components. Upon installation, the LCMS-8050 will deliver LCMS-8060 performance.
- Improved ion sampling efficiency DL (Desolvation Line)
- Improved ion guide with enhanced focusing capabilities UF-Qarray Enhanced vacuum efficiency
- Improved the CID efficiency Rotary pump
Development of UF-Qarray Ion Guide using Shimadzu’s Simulation Technologies
The new UF-Qarray was designed to maximize sensitivity without compromising robustness or changing the minimal noise performance established in our previously patented Qarray. To optimize the design of the UF-Qarray, a number of simulation studies were carefully conducted using two platforms to model ion behavior under increased gas flow in the low vacuum region. FLUENT software was used to determine which pole shape would maximize ion focusing under gas flows generated by the enhanced pumping configuration (Fig. 1). The second technology, newly developed Optdesign modelling software, was used to analyze the complex behavior of ion trajectories when voltages are applied to the expanded ion cloud (Fig. 2). Using FLUENT and Optdesign simulation models, several prototypes were developed for testing, which led to the UF-Qarray pole geometry final design. This design ejects neutral gas particles in order to reduce noise while achieving greater ion focusing than the previous Qarray design.
Fig. 1 Gas Flow Simulation Results Using FLUENT
Fig. 2 Ion Trajectory Simulation Results Using Optdesign
Groundbreaking Technology for High Sensitivity
With the newly designed UF-Qarray, improved ion focusing efficiency results in greater signal intensity and a reduction in noise. By improving the ion sampling device (desolvation line) and the ion guide (UF-Qarray), and enhancing the vacuum efficiency, the LCMS-8060 defines sensitivity. These new technologies allow for improvements in sensitivity and robustness in all acquisition modes.
LC-MS Consumables
Application Specific LC-MS Systems
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This MRM library includes two methods: one for phospholipid classification by comprehensive analysis of the main phospholipids in biological samples, and one for fatty acid composition determination created using analytical results obtained with the classification method. -
Provides procedures and methods for analyzing organofluorine compounds in drinking water according to EPA Methods 533 and 537.1 -
Lipid mediators (bioactive lipids) have important physiological functions and have been associated with allergies, thrombosis and lifestyle-related diseases. -
Shimadzu Method Packages deliver conditions for efficient and simultaneous multi-component analysis. -
This Method Package enables the analysis of 144 compounds in under 20 minutes per sample. -
An enormous number of MRM conditions need to be evaluated in order to analyze a large number of proteins. -
Complete method for fast quantitative screening of 13 aminoglycosides in meat, eggs and milk. -
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation? -
Method package including 129 veterinary drug compounds, more than 3 times as many as Ver. 1 -
Shimadzu provides method files, including pre-registered MRM parameters with optimized quantitative and reference ions, LC separation parameters, and retention times and peak identification parameters for each compound, as well as report templates for outputting quantitation results, as a package. -
Database compatible with LabSolutions Connect, a tool that automates MRM tuning and optimization -
The Forensic Toxicology Database includes optimized LC-MS/MS data acquisition parameters and a library database to help clinical and forensic researchers build screening and quantitation methods quickly, simplifying method development. -
This system improves the efficiency of simultaneous LC/MS/MS analysis methods by allowing the user to start analysis without time-consuming steps such as consideration of separation conditions and MS parameter optimization. -
Most important amino acids exist as stereoisomers. -
In recent years, while many issues have been raised related to food safety and the environment, the safety of textiles, which are indispensable for everyday life, has become a particular concern. -
Mycotoxins are highly toxic chemical byproducts from fungi commonly found in crops, and residual content in foods are regulated the world over. -
Of the short-chain fatty acids produced by intestinal bacteria, acetic acid, propionic acid, and butyric acid are well known, and it has been reported that there are some connections between them and lifestyle-related diseases such as obesity and diabetes. -
This LC/MS/MS Method Package for Reactive Sulfur Profiling offers analytical methods for LC/MS/MS that target all 17 sulfur-containing metabolites, including reactive sulfur species, with separation conditions and MS parameters that are optimized for each compound.
LC-MS Software
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Optional software for the LC/MS/MS Method Packages for Primary Metabolites and Cell Culture Profiling -
Due to increasingly sophisticated automation, large quantities of high-quality mass spectrometer data can be obtained day and night. -
Traverse MS data analysis software is intended for high-speed processing of MRM data acquired with Shimadzu triple quadrupole LCMS systems in the field of targeted metabolomics.
Software Options
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LabSolutions Connect can perform everything from execution of the optimization of MRM transitions and interface parameters to checking of the optimization results, creation of method and batch files for quantitative analysis, and quantitative calculations. -
LabSolutions Insight Library Screening is optional software for LabSolutions Insight.
LabSolutions Series
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LabSolutions DB has a data management function and is compliant with the ER/ES Regulations. It is optimally configured for customers using a PC. -
LabSolutions CS features an innovative operating environment and provides complete data management to ensure secure information in networked laboratories.
Related information
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The LCMS-8045 was designed to be robust. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity and minimize contamination. -
The LCMS-8060NX is a triple quadrupole mass spectrometer with world-class sensitivity and detection speeds. It boasts increased robustness and ease of use as well as Analytical Intelligence to maximize your laboratory’s output. -
This Method Package allows comprehensive analysis of 49 Bile Acids from plasma, urine and feces. Bile Acids are essential for cholesterol metabolism and play a key role in absorption of fats in the small intestine. Additionally, they serve as signaling molecules that regulate metabolism. -
Triple quadrupole mass spectrometry (TQMS) is a versatile tool for quantitative analysis. Experience the excellent performance and robustness of Shimadzu’s LCMS-TQ instruments, which offer a choice of speed, sensitivity and resolution to meet the demands of high-throughput routine analysis and/or more specialized applications.
Compare Shimadzu’s triple quadrupole LC-MS/MS systems below.
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nSMOL (nano-surface and molecular orientation limited proteolysis) is Shimadzu’s proprietary, innovative technique that enables selective proteolysis of the Fab region of monoclonal antibodies. -
The Multi-omics Analysis Package, developed for metabolic engineering applications, provides the ability to automatically generate metabolic maps and perform a variety of data analysis for the vast data generated in fields like metabolomics, proteomics and flux analysis. -
Provides Sample Preparation Protocols and Analytical Methodsfor Glycosaminoglycans that Cause Mucopolysaccharidosis
