Comprehensive 2D-LC is a analytical methodology combining two independent separation modes orthogonally, greatly increasing separation efficiency.
Nexera-e
Comprehensive Two-Dimensional Liquid Chromatograph
Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved.
The new Nexera-e is the ideal solution for the separation and characterization of most challenging and complex samples. It is particularly useful for the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.
Improved resolving power compared to conventional 1D-LC
How many peaks are co-eluted under one peak? The more complex the sample, along with a high percentage of similar compounds, there exists a high probability of co-eluting compounds found under single peaks.
Even though the co-eluting compounds may not be separated by mono-dimensional separation, an orthogonal two-dimensional system will provide the best possible result.
Comparison of chromatograms (traditional Chinese medicine)
Features
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Shimadzu triple quadrupole mass spectrometers (TQMS) have the world-class polarity reversal speed (5 ms) and data capture speed (1.5 ms). In comprehensive 2D-LC analysis, the analysis time of second dimension is short, therefore the high-speed performance of the LC-MS affects the quality of the data. -
Comprehensive 2D-LC often requires complicated software operation for setting 1D and 2D analytical conditions. LabSolutions provides an easy parameter setting and contributes to the simple operation.
Downloads
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Applications
| Documents | Date Creation Date |
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2023-05-14 | |
2023-05-14 | |
2022-08-23 |
Technical Documents
| Documents | Date Creation Date |
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2024-01-21 | |
2023-10-24 | |
2022-05-30 |
News / Events
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New Method Development System
LabSolutions™ MD improves method development efficiency by taking an Analytical Quality by Design (AQbD) approach. This software efficiently develops highly reliable analysis methods by configuring mobile phases, columns, and other parameters using an analysis function that automatically generates analysis schedules with the experimental design method and a data analysis function that plots a design space and predicted chromatogram.
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New Nexera Prep Preparative Purification Liquid Chromatograph
The Nexera™ Prep Purification System provides optimal solutions for your laboratory needs.
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Shimadzu has released the Shim-vial™ H glass, S glass.
Shimadzu provides high-quality vials that thoroughly eliminate these risks by visually inspecting each vial, allowing them to be used with confidence.
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Shimadzu has released the MUP-3100, Fully Automated Sample Preparation Module for Glycan Analysis
Shimadzu developed the MUP-3100 Fully Automated Sample Preparation Module for Glycan Analysis in conjunction with Sumitomo Bakelite Co., Ltd., for use with their antibody N-glycan analysis kit. The MUP-3100 eliminates manual sample preparation, increases overall analysis throughput, and improves reproducibility.
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Ion Chromatography Solutions for Environmental Analysis
Shimadzu has focused on the development of instruments for environmental analysis for decades, helping scientists to detect, identify and quantify trace-level pollutants and meet environmental testing demands, for both regulatory purposes and to advance Research & Development.
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Shimadzu has released the Peakintelligence™ for LC
Liquid chromatography is now an indispensable analytical technique used in pharmaceutical, food, and a wide variety of other industries. In these industries, there is a need for efficient data analysis methods that are not user-dependent. Peakintelligence for LC software includes AI algorithm* that was developed by learning expert peak integration skills.