High throughput molecular weight confirmation of Pharmaceutical Compounds using DART MS analysis with ultra-fast polarity switching
DART, a direct atmospheric pressure ionization source, is known to have little or no negative effect from the solvent used to dissolve the sample. Even with problematic solvents for LC/MS operation such as non-volatile solvents or solvents containing salt, the target compounds can be instantly identified using DART-MS without any sample preparation. High-throughput MW confirmation of synthesized compounds is difficult to achieve using time of flight mass spectrometers, which have been a common choice to interface DART, due to its limitation in switching between positive and negative ion modes.
By combining an automated DART ion source with a quadrupole mass spectrometer with ultra-fast polarity switching capability, 11 different pharmaceutical compounds with various polarities were successfully determined in approximately 10 sec/sample.
- Content Type:
- Paper
- Document Number:
- PO-CON1210E
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
- Keywords:
- Ultra-fast Polarity Switching, Direct Analysis in Real Time, Pharmaceutical Compounds, DMSO, Pharmaceutical, Life Science, CRO, DART, LCMS-2020
- Language:
- English
- File Name:
- jpo112156.pdf
- File Size:
- 416kb