Qualitative Analysis of Drug Metabolites Using LCMS-9050

User Benefits

- The LCMS-9050 quadrupole time-of-flight (Q-TOF) mass spectrometer and LabSolutions Insight Explore™ provide qualitative analysis of drug metabolites. - Analyze and Target Screening function in LabSolutions Insight Explore enables peak extraction of candidate drug metabolites.

Introduction

After a drug is ingested into the body, it is metabolized by various reactions, including oxidation, reduction, hydrolysis, and conjugation. The prediction of drug metabolites is important because the metabolites may differ from the original drug in terms of efficacy and toxicity. This Application News introduces an example of qualitative analysis of drug metabolites using the LCMS-9050 quadrupole time-of-flight (Q-TOF) mass spectrometer. Lenvatinib, a known anticancer drug, was administered orally to rats, and the metabolites in the liver were analyzed. Drug metabolite peaks were extracted using the Analyze function in LabSolutions Insight Explore. The Target Screening function narrowed down the candidate peaks based on a list of drug metabolites, and the MS and MS/MS spectra were analyzed in detail.

July 11, 2024 GMT