Distribution Analysis of Plant Alkaloids in Narcissus, by MS Imaging

User Benefits

- Qualitative screening using the DPiMS QT kit can be conducted with measurement time of approximately 0.5 min. - Easily switch between DPiMS QT and iMScope QT. - Distribution analysis using iMScope QT is expected to improve the efficiency of drug production.

Introduction

Plant alkaloids are used in various pharmaceuticals, such as anticancer drugs and analgesics. Among these plant alkaloids, galanthamine is an Amaryllidaceae-type alkaloid with acetylcholinesterase inhibitors used in the treatment of neurological diseases such as Alzheimer's disease. Although the chemical synthesis of galanthamine has been successfully achieved, Narcissus is the main source of its production. Research indicates that galanthamine content varies not only with the type of Narcissus, but also with the developmental stage and the part of the plant. Pharmaceutical companies are pursuing plant species with higher galanthamine content to increase pharmaceutical productivity. In this study, we were able to quickly confirm the presence of galanthamine in our Narcissus sample using the DPiMS QT probe electrospray ionization (PESI) kit and the LCMS quadrupole time-of-flight (Q-TOF) mass spectrometer (MS) . Subsequently, we analyzed the distribution of galanthamine by MS imaging (MSI) using the iMScope QT and the LCMS Q-TOF MS.

March 18, 2025 GMT