Determination of Essential and Toxic Elements in Urine by ICPMS-2050

User Benefits

- Utilizing CRM Urine Control samples streamlines the workflow and minimizes the risk of errors. - ICPMS-2050 can achieve accurate analysis with lower argon gas consumption and running cost using mini torch. - Internal standard fluctuation can be readily observed using the Internal Standard Intensity Fluctuation Graph function of LabSolutions ICPMS.

Introduction

Biomonitoring is the process of measuring specific chemicals or metabolites in biological specimens, such as urine and blood serum. It is an important tool for assessing human exposure to environmental contaminants. One of the methods involves measuring the concentration of trace elements, such as arsenic, cadmium, lead and mercury. Urine is an ideal sample for biomonitoring because the sample collection is both non-invasive and relatively simple. In addition, many trace elements are excreted predominantly in urine as their original form or metabolites. Graphite furnace atomic absorption spectrometry (GFAAS) has been used by clinical laboratories to determine trace elements in urine. However, as GFAAS is a mono-elemental technique, the analysis could be time consuming when many samples are measured for multiple element analysis. In recent years, Inductively Coupled Plasma Mass Spectrometry (ICP-MS) has become the preferred technique for urine analysis due to its ability to detect multiple elements simultaneously, wide dynamic linear range and high sensitivity. Furthermore, with collision/reaction cell technology equipped in ICP-MS, interference such as polyatomic interference can be eliminated. In this study, an ICP-MS method was developed to determine the concentration of nineteen toxic and essential elements in certified reference material (CRM) of urine using Shimadzu ICPMS-2050.

March 20, 2025 GMT