Endocrine disrupters

Nonylphenol (NP) is used as a raw material to produce surfactants and as an antioxidant used to protect rubber and plastics, etc., but recently it has been specified as a substance that can cause endocrine disruption in the environment.
We decided to investigate NP with a triple quadrupole gas chromatograph-mass spectrometer (GC-MS/MS) with high m/z selectivity . By optimizing the MS/MS analytical conditions, selective detection of thirteen 4-NP isomers was achieved with high sensitivity. Furthermore, in the analysis of NP in river water, which typically contains many contaminants, analysis was possible without adversely affecting identification accuracy, even when omitting the cleanup procedure which normally lowers the sample recovery rate. /p>

In recent years, chemical discharge incidents have increased on a global scale, heightening demands for the identification of unanticipated chemical substances in order to investigate causes and take necessary measures.
This article introduces an example of screening for environmental pollutant PCBs and chlorinated pesticides, which are compounds suitable for MRM measurements, by applying Compound Composer Database Software to the scan data acquired in simultaneous scan/MRM measurements.

We have introduced a multi-valve column switching HPLC system with a specially designed pretreatment column. This column-switching system solved a recurrent issue of column clogging and the MASK-ENV pretreatment column provided remarkable performance for removal of humic compounds from environmental water samples. 1 ng/L of bisphenol A (BPA) (which is an endocrine disruptor) could be detected by using the universal fluorescence detector RF-20Axs along with the 2-valve column switching pretreatment system.