Trap-Free 2D LC/MS system for Quadrupole LCMS
Enhancing the Efficiency of Impurity Analysis
Question:
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation?
Answer:
With the use of a Trap-free 2D LCMS system, no additional method development is required because mobile phases can be changed online.
- Online switching between a non-volatile mobile phase and a volatile mobile phase
- Convenient support tool coordinated within LabSolutions
- Only the impurities of interest are introduced to the MS system, so there are no concerns about peak misalignment.
Creating a Time Program and Batch Schedule using the Support Tool
The optimal valve sequence can be constructed by entering the retention times for impurity peaks observed in the first-dimension UV chromatogram, and then a batch schedule can be created to acquire data on multiple impurities and their respective blanks.
Using the Data Browser Makes Identification of Impurities Easy
Example of sample data and blank data displayed in the data browser
Remarks and Precautions
- The Trap-Free 2D LCMS System is a application system and is configured with LC units, Quadrupole mass spectrometer, and start kit
News / Events
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Perform forensic toxicology screening for drugs of abuse, psychotropic drugs, pharmaceuticals, pesticides, and natural toxins using this high-resolution accurate mass database.
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Shimadzu has released the Shim-vial™ H glass, S glass.
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INTERNATIONAL MASS SPECTROMETRY CONFERENCE 2024
Visit the Shimadzu booth at the International Mass Spectrometry Conference (IMSC) 2024.
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Shimadzu Lunch Presentation at Metabolomics 2024
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Shimadzu has released the LCMS-TQ RX Series High-Performance Liquid Chromatograph Mass Spectrometers
Innovative technology, exceptional design and new ways of thinking are part of our engineering DNA delivering solutions for the ever-changing needs of any laboratory. As our scientific and business needs change our engineering design evolves and adapts. The result is the RX Series of triple quadrupole LC-MS instruments designed with unmatched capability, redefined reliability and creating a new standard in actionable data.