Trap-Free 2D LC/MS system for Quadrupole LCMS
Enhancing the Efficiency of Impurity Analysis
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Question:
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation?
Answer:
With the use of a Trap-free 2D LCMS system, no additional method development is required because mobile phases can be changed online.
- Online switching between a non-volatile mobile phase and a volatile mobile phase
- Convenient support tool coordinated within LabSolutions
- Only the impurities of interest are introduced to the MS system, so there are no concerns about peak misalignment.
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Creating a Time Program and Batch Schedule using the Support Tool
The optimal valve sequence can be constructed by entering the retention times for impurity peaks observed in the first-dimension UV chromatogram, and then a batch schedule can be created to acquire data on multiple impurities and their respective blanks.
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Using the Data Browser Makes Identification of Impurities Easy
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Example of sample data and blank data displayed in the data browser
Remarks and Precautions
- The Trap-Free 2D LCMS System is a application system and is configured with LC units, Quadrupole mass spectrometer, and start kit
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