Nexera-e
Comprehensive Two-Dimensional Liquid Chromatograph
Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved.
The new Nexera-e is the ideal solution for the separation and characterization of most challenging and complex samples. It is particularly useful for the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.
Improved resolving power compared to conventional 1D-LC
How many peaks are co-eluted under one peak? The more complex the sample, along with a high percentage of similar compounds, there exists a high probability of co-eluting compounds found under single peaks.
Even though the co-eluting compounds may not be separated by mono-dimensional separation, an orthogonal two-dimensional system will provide the best possible result.
![Improved resolving power compared to conventional 1D-LC](/an/sites/shimadzu.com.an/files/d7/ckeditor/an/hplc/nexera/nexera-e/improved_resolving_power_compared_to_conventional_1d-lc.jpg)
Comparison of chromatograms (traditional Chinese medicine)
Features
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Comprehensive 2D-LC is a analytical methodology combining two independent separation modes orthogonally, greatly increasing separation efficiency.
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Shimadzu triple quadrupole mass spectrometers (TQMS) have the world-class polarity reversal speed (5 ms) and data capture speed (1.5 ms). In comprehensive 2D-LC analysis, the analysis time of second dimension is short, therefore the high-speed performance of the LC-MS affects the quality of the data.
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Comprehensive 2D-LC often requires complicated software operation for setting 1D and 2D analytical conditions. LabSolutions provides an easy parameter setting and contributes to the simple operation.
News / Events
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Shimadzu has released the Peakintelligenceā¢ for LC
Liquid chromatography is now an indispensable analytical technique used in pharmaceutical, food, and a wide variety of other industries. In these industries, there is a need for efficient data analysis methods that are not user-dependent. Peakintelligence for LC software includes AI algorithm* that was developed by learning expert peak integration skills.
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Oxygen heterocyclic compounds profile evaluation in cold-pressed Citrus essential oils using supercritical fluid chromatography coupled to photodiode array detector
A large number of analytical techniques to characterize the non-volatile composition of Citrus essential oils (EOs) were introduced in the literature. However, the reports of Citrus EOs analysis by supercritical fluid chromatography (SFC) with UV or mass spectrometry detectors for the analysis of non-volatile polar compounds are still few.
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Shimadzu has released the Shim-pack Mix-HILIC, Chromatography Column for Hydrophilic Interactions
Comprehensive Analysis of Hydrophilic Metabolites in Metabolomics
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A new video has been released -Finding Out What Makes Things Sour-
Ever wondered what makes some foods sour? In this video we explore that question while also introducing one of Japan's traditional sour foods!
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New Nexera FV
Nexera FV and LabSolutionsā¢ FV together form a new UHPLC system capable of monitoring flow synthesis and batch synthesis reactions, and automating formulation dissolution testing.
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Pharmaceutical and Biopharmaceutical has been updated.
Shimadzu Corporation has always been a reliable partner for the pharmaceutical industry. We provide comprehensive analytical solutions for all drug research analysis and productions and help companies to increase efficiency, reduce cost, and ensure drug safety and quality.