Shimadzu Review Vol.80[3・4](2023)
Diagnostics

SPECIALLY COLLECTED PAPERS

Development of a Novel Method for Quantifying Exosomes and Surface Antigens

by Makoto Watanabe, Ph.D.1Chikage Aoki, Taka-aki Sato, Ph.D.1Yuta Miyazawa2Yoshikazu Sou2

Shimadzu Review 80[3・4] (2023)

Abstract

Exosomes (small extracellular vesicles) are produced by a variety of different cells and have garnered significant interest in recent years. Exosomes can encapsulate proteins, lipids, and nucleic acids, making them a highly promising platform for clinical applications in diagnosis and treatment as well as industrial applications in cosmetics and food. Based on this potential, exosomes have become a focus of research and development in academia as well as in numer-ous companies and the market for this field of research is growing rapidly. Our team has developed a rapid quantitative assay for exosomes using immunochromatography. We have also developed a system for quantifying multiple exosome surface antigens by using metal-labeled antibodies and mass spectrometry. This article describes these novel methods and presents prospects for their future use.


1Life Science Research Center, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan
2Functional Materials Development Group, Specialty Business Dept., Specialty Business Div., Dai Nippon Toryo Co., Ltd, Osaka, Japan

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