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Shimadzu Review 80[3・4] (2023)
Abstract
Microphysiological systems (MPS) are attracting increasing interest as a new tool capable of resolving the recent trend toward the prohibition of animal experiments and potentially addressing the interspecies differences between laboratory animals and humans. We are developing a pressure-driven microphysiological system (PD-MPS) as part of our participation in a Japan Agency for Medical Research and Development (AMED) project. The system uses devices that resembles a conventional well plate in shape but features the ability to transport culture medium between the wells through flow channels formed in the bottom of the wells. Air pressure-driven liquid transfer is used to allow the device to operate with less piping than fluidic devices that use conventional pumps, and a device holder is used to ensure connecting the device to compressed air piping is a simple procedure. This article provides an overview of the device in development, the status of system development for the device, and evaluates using the PD-MPS for drug permeability assays.
1Biology-Chemistry Unit Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan
2Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan
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