LabSolutions Insight Biologics

Software for Oligonucleotide Sequence Characterization

Supporting Innovation with Oligonucleotide Therapeutics

LabSolutions Insight Biologics is software for analyzing the characteristics of oligonucleotides using single quadrupole (SQ) mass spectrometers, quadrupole time-of-flight (QTOF) mass spectrometers, or MALDI ionization mass spectrometers. Analyzing the characteristics of oligonucleotides involves the identification of impurities and sequence confirmation with modification positions estimated. Performing these analyses using a complicated mass spectrum requires a great deal of time. Additionally, using multiple software programs for the measurements and data analysis complicates the operations, and puts considerable strain on the operator. LabSolutions Insight Biologics was designed to resolve these issues.

With LabSolutions Insight Biologics, it is easy to configure the primary component sequence and data analysis parameters. Then using the sequence entered, the program can comprehensively identify chain length differences, nucleotide gaps, modifications, ion adducts, and other impurities. The molecular weights of the primary components and impurities are estimated with the MS1 spectrum, and the sequence is estimated from the fragment spectra of the impurities. Also, the sequence validity can be confirmed by visually checking the fragment coverage. LabSolutions Insight Biologics is all-in-one LabSolutions series software. After measurements with LabSolutions, the data analysis is implemented automatically with the specified parameters, so when the measurements are started, everything up to the display of the analysis results is performed seamlessly.

Capable of Analyzing LCMS-SQ, LCMS-QTOF, and MALDI Data

In addition to QTOF, LabSolutions Insight Biologics can analyze SQ and MALDI data. When QTOF is used, high-accuracy results are obtained, while SQ and MALDI can be used for applications where convenient measurement is prioritized. In process management, everything from the establishment of efficient processes to productivity improvements can be implemented, and it can be used in research and development in a variety of fields. The data analysis parameters can be conveniently deployed even in workflows with different instruments, so there is no need to remember new operations.

LabSolutions Insight, LabSolutions and Nexera are trademarks of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.
MALDI-8020 and MALDI-8030 are trademarks of Kratos Analytical Ltd.
Windows is either a registered trademark or a trademark of Microsoft Corporation in the United States and/or other countries.

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