Nexera Prep - Specs
Preparative Purification Liquid Chromatograph
Excellent System Expandability
Solvent Delivery Unit Accommodates a Wide Range of Recovery Volumes
Guidelines for Preparative Scale and Maximum Load
The figure at right shows the guidelines for total component capacity with a 250 mm long column when the target component is highly soluble in the mobile phase, separates from impurities, and ions are suppressed. For isocratic elution, in principle, the total component capacity is proportional to the column volume.
LC-40D
Supports a Range of Applications from High-Precision Analytical to Semi-Preparative
LC-40D
- This solvent delivery unit can handle flow rates ranging from those used in analytical scale to those used in semi-preparative (up to 10 mL/min).
- High-precision analysis is possible even in the semi-micro flow-rate range.
LC-20AP
Supports Large-Scale Preparative Fractionation
LC-20AP
- High flow rates (up to 150 mL/min) enable highly efficient, large-scale preparative fractionation.
- Large-scale prep solvent delivery fully supports the preparative fractionation workflow, including reinjection, to assess purity.
- Combine with an FCV-200AL low-pressure gradient unit to perform gradient analysis using up to four mobile phases.
| LC-40D | LC-20AR | LC-20AP | |
|---|---|---|---|
| Solvent Delivery Method | Parallel-type double plunger | ||
| Plunger Capacity | 10 μL | 47 μL | 250 μL |
| Maximum Discharge Pressure | 44 MPa | 49 MPa | 42 MPa |
| Flow Rate Setting Range | 0.0001 to 5.0000 mL/min (1.0 to 44 MPa) 5.0001 to 10.0000 mL/min (1.0 to 22 MPa) |
0.01 to 20.00 mL/min | 0.01 to 150.00 mL/min |
| Flow Rate Accuracy | No more than ±1% or ±2 μL/min, whichever is greater (under specified conditions) |
No more than ±1% or ±10 μL/min, whichever is greater (0.1 to 5.0 mL/min |
No more than ±1% (1 mL/min, 10 MPa) |
| Flow Rate Precision | No more than 0.06% RSD or 0.02 min SD, whichever is greater | No more than 0.08% RSD or 0.02 min SD, whichever is greater | No more than 0.1% RSD or 0.02 min SD, whichever is greater |
| Constant Pressure Solvent Delivery | Supported | ||
| Plunger Rinsing Mechanism | Optional available | Syringe or rinsing pump (228-39625-41) | Syringe or rinsing pump (228-39625-41) |
| Operating Temperature Range | 4 to 35°C | ||
| Size and Weight | W260 × H140 × D500 mm, 10 kg | W260 × H140 × D500 mm, 16 kg | W260 × H210 × D500 mm, 19 kg |
LC-40D
LC-40D
• This solvent delivery unit can handle flow rates ranging from those used in analytical scale to those used in semi-preparative (up to 10 mL/min).
• High-precision analysis is possible even in the semi-micro flow-rate range.
Guidelines for Preparative Scale and Maximum Load
| Solvent delivery method |
Parallel-type double plunger |
|---|---|
| Plunger capacity |
10 μL |
| Maximum discharge pressure |
44 MPa |
| Flow rate setting range |
0.0001 to 5.0000 mL/min (1.0 to 44 MPa) |
| Flow rate accuracy |
No more than ±1% or ±2 μL/min, whichever |
| Flow rate precision |
No more than 0.06% RSD or 0.02 min SD, whichever is greater |
| Constant pressure solvent delivery |
Supported |
| Plunger rinsing mechanism |
Optional available |
| Operating temperature range |
4 to 35 °C |
| Size and weight |
W260 × D500 × H140 mm, 10 kg |
LC-20AR
This solvent delivery unit can handle flow rates used in semi-preparative scale (up to 20 mL/min).
Using a recycle kit enables semi-preparative recycling.
Supports Semi-Preparative and Recycle Preparative
| Solvent delivery method |
Parallel-type double plunger |
|---|---|
| Plunger capacity |
47 μL |
| Maximum discharge pressure |
49 Mpa |
| Flow rate setting range |
0.001 to 20.000 mL/min |
| Flow rate accuracy |
No more than ±1% or ±10 μL/min,whichever is greater (0.1 to 5.0 mL/min) |
| Flow rate precision |
No more than 0.08% RSD or 0.02 min SD, whichever is greater |
| Constant pressure solvent delivery |
Supported |
| Plunger rinsing mechanism |
Syringe or rinsing pump |
| Operating temperature range |
4 to 35 °C |
| Size and weight |
W 260 x H140 x D 500 mm，16 kg |
LC-20AP
High flow rates (up to 150 mL/min) enable highly efficient, large-scale preparative fractionation.
Large-scale prep solvent delivery fully supports the preparative fractionation workflow including reinjection to assess purity.
Combine with an FCV-200AL low-pressure gradient unit to perform gradient analysis using up to four mobile phases.
Supports Large-Scale Preparative Fractionation
| Solvent delivery method |
Parallel-type double plunger |
|---|---|
| Plunger capacity |
250 μL |
| Maximum discharge pressure |
42 Mpa |
| Flow rate setting range |
0.01 to 150.00 mL/min |
| Flow rate accuracy |
No more than ±1% (1 mL/min, 10 MPa) |
| Flow rate precision |
No more than 0.1% RSD or 0.02 min SD,whichever is greater |
| Constant pressure solvent delivery |
Supported |
| Plunger rinsing mechanism |
Syringe or rinsing pump |
| Operating temperature range |
4 to 35 °C |
| Size and weight |
W 260 x H210 x D 500 mm，19 kg |
Shim-pack Scepter Columns
- Excellent stability & performance using a wide range of LC conditions -
Shim-pack Scepter LC columns, which are the next generation organic silica hybrid based columns, are designed for stability and performance in a wide range of mobile phase conditions. With different chemistry characteristics, Shim-pack Scepter columns are effective for method development/scouting under conditions that may compromise traditional silica based columns.
With different particle sizes (1.9 μm, 3 μm, 5 μm) and different column dimensions, Shim-pack Scepter LC columns are fully scalable between UHPLC, HPLC and preparative LC, making method transfer seamless between different laboratory instrumentation.
| Shim-pack Scepter | Reversed Phase | ||||
|---|---|---|---|---|---|
| C18 | HD-C18 | C8 | Phenyl | PFPP | |
| Functional Group | Trifunctional C18 | Trifunctional C18 | Trifunctional C8 | Trifunctional Phenylbutyl |
Trifunctional Pentafluorophenylpropyl |
| Generic Purpose Type | High Density Type | ||||
| Particle | Organic Silica Hybrid | ||||
| Particle Size | 1.9 μm，3 μm，5 μm | ||||
| Pore Size | 12 nm | 8 nm | 12 nm | ||
| End Capping | Proprietary | None | |||
| pH Range | 1 - 12 | 1 - 10 | 1 - 8 | ||
| 100% Aqueous Condition | Yes | No | No | Yes | Yes |
| USP Classification | L1 | L1 | L7 | L11 | L43 |