Nexera XS inert - Configuration

The Nexera XS inert system eliminates the risk of sample adsorption or surface corrosion, while still providing all the exceptional features of the Nexera series, making it the perfect solution for a wide variety of applications.

Inhibits Metal Adsorption and Achieves 105 MPa Pressure Capacity

To reduce the various chromatogram problems that metal adsorption can cause, the Nexera XS inert features sample flow channels made with PEEK material. Though it is generally difficult to use PEEK plastic for high-pressure conditions, the PEEK-lined tubing (developed independently by Shimadzu) used in the Nexera XS inert offers a maximum pressure capacity of 105 MPa*. Furthermore, a proprietary butt-sealed tubing configuration eliminates the need for ferrules and results in tubing joints with no dead volume. In addition, a proprietary ratcheted fitting design allows column connections to be hand-tightened even at high pressures.

* Also supports mobile phases spiked with HFIP (max. 5 %).

 

High Corrosion Resistance and Broad pH Resistance

Nexera XS inert systems also offer superior corrosion resistance. To support mobile phases that contain high haloid salt concentrations for analyzing proteins, for example, corrosion-resistant metal is used for mobile phase contact surfaces upstream from the sample injection unit, such as in the solvent delivery pump and mixer, whereas PEEK plastic and ceramic materials are used for sample contact surfaces. In addition, the superior pH resistance of PEEK plastic ensures the system can be used to reliably acquire data for long periods even when using high-pH* mobile phases, such as for oligonucleic acid analysis.

* Supports pH levels from 1 to 14.

Example of Analyzing mAb Aggregates Using a Mobile Phase with a High Haloid Salt Concentration